Ултра концентрирана ОМЕГА 3

В кои случаи може да се използва Омега 3? Сърдечно-съдови заболявания и атеросклероза (за намаляване на нивата на триглицеридите и LDL холестерола, и поддържане на нормално кръвно налягане) Заболявания на ставите Деменция За по-добро функциониране на имунната система За по-добро зрение и при макулна дегенерация при възрастни За образуване на по-голямо количество сперматозоиди и подобряване на подвижността им При бременни, за правилно развитие на плода Средна хранителна информация за 5 ml: Масло от диви, студеноводни риби… 4650 mg …от които Омега 3 1 … 3664 mg …от които Ейкозапентаенова киселина (ЕПК) 1 1832 mg …от които Докозахексаенова киселина (ДХК) 1 1374 mg 1 Под формата на триглицериди Без лактоза, глутен и ГМО! Какво представляват Омега 3 мастните киселини и за какво служат? Омега 3 мастните киселини са наречени есенциални, тъй като те не могат да се произвеждат от организма и трябва да се набавят с храната. Алфа-линоленовата киселина (АЛК) се открива в някои растения като: семена (лен, чиа), ядки (орехи) и масла (соя, рапица). В черния дроб AЛК се превръща в Докозахексаенова киселина (ДХК), след това тя в Ейкозапентаенова киселина (EПК). Последната е основен източник на простагландини от тип 3 ( ПГ3), с противовъзпалителни, антиалергични и съдоразширяващи свойства.     ДХК и ЕПК са в най-голяма концентрация в морските продукти и спомагат за правилното функциониране на сърцето, мозъка и очите.   Омега 3 имат различни въздействия, като някои механизми все още не са изяснени напълно: Те са универсалните съставки на биологичните мембрани на всички клетки в организма Осигуряват активността на протеините, които съдържат Използват се за покриване на енергийни нужди на организма. Омега 3 могат да се превърнат в АТФ в митохондриите или да се съхраняват в мастните клетки като триглицериди Имат невропротективни свойства и участват в много мозъчни и когнитивни функции като запаметяване, възприятие и концентрация Омега 3 са основни структурни съставки на централната нервна система и обуславят правилното функциониране на нервните клетки Участват в междуклетъчната комуникация, по-специално чрез процесите на невротрансмисия (миелинова обвивка) Те имат важно действие за регулиране на голям брой гени, чрез активиране на транскрипционни фактори, клетъчния растеж и диференциация   Защо е нужен допълнителен прием на ДХК и ЕПК? Учените установяват, че преобразуването на Омега 3 мастни киселини от предшественика им АЛК в клетката, не е много активно. Той се влияе много фактори като: възраст, пол, стрес или генетично предразположение. Клиничните изследвания  показат, че само от 2 до10% от консумираната АЛК се превръща в ЕПК или ДХК 1 . Следователно е от съществено значение да осигурим чрез храната, директни източници на ЕПК и ДХК за нашето тяло. Значителни количества ЕПК и ДХК има във всички мазни риби, които се хранят с водорасли и фитопланктон (сьомга, скумрия, сардини, херинга и др.), морски дарове, крил, рибени масла… От 2010 г. Френската агенция за контрол на храните,  препоръчва прием на ЕПК и ДХК от 500 mg на ден за възрастен. Данните обаче показват, че консумацията на АЛК в количества, достъпни чрез обичайната диета, не са достатъчни, за да задоволят нуждите на организма от Омега 3 (и по-специално от ДХК). Поради това е необходимо допълнителен прием на Омега-3 и по-специално на ЕПК и ДХК! С тази цел COPMED разработиха Ултра концентрирана Омега 3, с високо съдържание на ЕПК и ДХК. ОМЕГА 3 в този продукт е от следните диви, студеноводни риби: Перуанска аншоа, Европейска сардина, скумрия и Европейска аншоа. ChiuCC,SuKP,ChengTC,LiuHC,ChangCJ,DeweyME,StewartR,Huang SY. The effects of omega-3 fatty acids monotherapy in Alzheimer’sdisease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog Neuropsychopharmacol Biol Psychi-atry. 2008;32:1538–44.     Начин на  употреба: 1 чаена лъжичка (5 ml) на ден, по време на хранене. Опаковка:  125 ml Защо избрахме норвежката фирма Epax? Гарантирана чистота и качество Epax е най-големият норвежки производител на Омега 3! Продуктите му се отличават с изключителна чистота и качество (трайност, проследимост и безопасност). Epax има над 170 години опит в областта на морската биология. Компанията е член на Глобалния консорциум на производителите на омега-3 (GOED). Но Хартата за качество на Epax далеч надхвърля нормите на GOED и действащите разпоредби. За премахване на различни замърсители и тежки метали от това масло, се използват патентовани процеси на молекулярна дестилация. Така се постигат несравними нива на чистота на маслото, 60 до 95% по-високо от настоящите Норвежката агенция по лекарствата, Европейската фармакопея и FDA! Маслото на Epax е без мирис и с нива на триглицериди от 90% ( 60% при конкурентите)!     Устойчив риболов Това масло се получава от малки, диви риби (сардини, аншоа, скумрия). Тези малки риби естествено съдържат много по-малко замърсители на околната среда, отколкото по-големите видове. Те се ловят в морето в съответствие с изискванията на екологично отговорния риболов и са сертифицирани от организацията „Friend of the Sea“ , за спазване на методите и устойчивостта на риболова. Освен че е сертифициран от „Friend of the Sеа“ , Epax е признат и от IFFO RS (Глобален стандарт за отговорно снабдяване). „Friend of the Sea“ е единствената програма за сертифициране на устойчив риболов, призната и контролирана в световен мащаб, като национален орган по акредитация. Гарантиран , нисък индекс TOTOX (показва степента на окисление) По дефиниция маслата, богати на полиненаситени мастни киселини, са податливи на окисляване. Това намалява хранителните им качества и влошава органолептичните характеристики. Получват се летливи молекули, които могат да усложнят храносмилането. Защитата на маслата срещу окислението започва от етапа на екстракция. Epax налага строги логистични спецификации за суровината: - Контролиране на температурите и нивата на кислород (      Висока бионаличност Благодарение на патента за естественото обогатяване на рибените масла с ЕПК и ДХК, се постига висока концентрация на Омега 3. Това позволява да се намали размерът на капсулите, като същевременно се запазват маслата в тяхната триглицеридна форма. Последната е най-често срещаната и води до по-добра бионаличност за организма!   Epax е компанията с най-много рецензирани, клинични изследвания ( над 100 на брой), свързани с Омега 3! Тези изследвания обхващат различни аспекти на медицината: кардиология, ревматология, неврология, акушерство, офталмология, имунология и др. Сърдечно-съдови заболявания von Schacky C, Angerer P, Kothny W. Et al. The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann.Intern.Med. 1999;130:554-562 von Schacky C, Baumann K, Angerer P. The effect of n-3 fatty acids on coronary atherosclerosis: results from SCIMO, an angiographic study, background and implications.LIPIDS 2001;36:S99-S102 Lervang HH, Schmidt EB, Møller JM. 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Effects of n-3 and n-6 fatty acids on platelet function and coagulation in healthy subjects. 1997;Uni Helsinki 75 Müllertz A, Hølmer G, Grøndahl-Hansen J et al. Increased concentration of plasminogen activator inhibitor type-1 in plasma after intake of fish oil. Fibrinolysis 1990;4(suppl 2):86-88 Christensen JH, Gustenhoff P, Korup E et al. n-3 polyunsaturated fatty acids, heart rate variability and ventricular arrhythmias in post-AMI-patients. A clinical controlled trial. Ugeskr.Laeger 1997;159:5526-5529 Christensen JH, Gustenhoff P, Korup E et al. Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. BMJ 1996;312:677-678 Christensen JH, Gustenhoff P, Ejlersen E et al. n-3 fatty acids and ventricular extrasystoles in patients with ventricular tachyarrhythmias. Nutrition Res 1995;15:1-8 Christensen JH, Gustenhoff P, Korup E et al. n-3 fatty acids and ventricular arrhythmias in post-myocardial infarction patients with a low ejection fraction 1995;10:107-114 Christensen JH, Christensen MS, Dyerberg J et al. Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n-3 fatty acids. Am J Clin Nutr 1999;70:331-337 Christensen JH, Aarøe J, Knudsen N et al. Heart rate variability and n-3 fatty acids in patients with chronic renal failure. Clin Neprol 1998;49:102-106 Kumar S, Sutherland F, Wheeler M, Heck PM, Lee G, Teh AW, Manohar LG, Morgan JG, Sparks PB. Effects of chronic omega-3 polyunsaturated fatty acid supplementation on human atrial mechanical function after reversion of atrial arrhythmias to sinus rhythm: Reversal of tachycardia-mediated atrial cardiomyopathy with fish oils. Heart Rhythm 2011;8:643-649 Seljeflot I, Arnesen H, Brude IR et al. Effects of omega-3 fatty acids and/or antioxidants on endothelial cell markers. Eur.J.Clin.Invest. 1998;28:629-635 Berstad P, Seljeflot I, Veierod MB et al. Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clinical.science 2003;105:13-20 Eid H, Arnesen H, Hjerkinn EM et al. Effect of diet and omega-3 fatty acid intervention on asymmetric dimethylarginine. Nutrition & Metabolism 2006;3:4 Furenes EB, Seljeflot I, Solheim S et al. Long-term influence of diet and/or omega-3 fatty acids on matrix metalloproteinase-9 and PAPP-A in men at high risk of coronary heart disease. SCLI 2008;68:177-184 Bonnema SJ, Jespersen LT, Marving J et al. Supplementation with olive oil rather than fish oil increases small arterial compliance in diabetic patients Diab Nutr & Metabol 1995;8:81-87 Hjerkinn EM, Seljeflot I, Ellingsen I et al. Influence of long-term intervention with dietary counseling, long-chain n-3 fatty acid supplements, or both on circulating markers of endothelial activation in men with long-standing hyperlipidemia. American.journal of clinical.nutrition 2005;81:583-589 Christensen JH, Therkelsen K, Møller JM et al. n-3 fatty acids do not decrease plasma endothelin levels in healthy individuals. Scan J Clin Invest 1997;57:495-500 Fashing P, Ratheiser K, Waldhäusl W et al. Metabolic effects of fish-oil supplementation in patients with impaired glucose tolerance. Diabetes 1991;40:583-589 Fashing P, Rohac M, Liener K et al. Fish oil supplementation versus gemfibrozil treatment in hyperlipidemic NIDDM. Horm Metab Res 1996;28:230-236 Troseid M, Seljeflot I, Hjerkinn EM et al. Il-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome. Diab Care 2008;32:486-492 Kamolrat T, Gray SR, and Thivierge MC. Fish oil positively regulates anabolic signalling alongside an increase in whole-body gluconeogenesis in ageing skeletal muscle. Eur J Nutr 2013;52(2):647-657 Flachs P, Rossmeisl M, and Kopecky J. The effect of n-3 fatty acids on glucose homeostasis and insulin sensitivity. Physiol Res 2014;63(1): 93-118 Kopecky J, et al. Combined intervention with Pioglitazone and n-3 fatty acids in metformin-treated diabetic patients on postprandial lipid clearance and selected cytokines. Nutrition & Metabolism NUAM-D-15-00080R1 Razny,U., Kiec-Wilk,B., Polus,A., Goralska,J., Malczewska-Malec,M., Wnek,D., Zdzienicka,A., Gruca,A., Childs,C.E., Kapusta,M., Slowinska-Solnica,K., Calder,P.C., and Dembinska-Kiec,A. 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Lipids in Health and Disease (2019) 18:31 https://doi.org/10.1186/s12944-019-0967-x   Ставни заболявания   Espersen GT, Grunnet N, Lervang HH et al.  Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids.  Clin Rheum 1992;11(3):393-395   Faarvang KL, Nielsen, Thomsen BS et al.  Fish oil and rheumatoid arthritis: a randomised double-blind study. Ugeskrift Laeger 1994;156:3495-3498   Hansen GVO, Nielsen L, Kluger E et al.  Nutritional status of Danish rheumatoid patients and effects of a diet adjusted in energy intake, fish-oil and antioxidants.  Scand J Rheumatol 1996;25:325-330   Nielsen GL, Faarvang BS, Thomsen BS et al.  The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis.  Eur J Clin Invest 1992;22:687-691   Volker DH, Fitzgerald P, Major G et al.  Efficacy of a fish-oil concentrate in the treatment of rheumatoid arthritis. J Rheumatol 2000;27:2343-2346   Sundstrom B, Stalnacke K, Hagfors L et al.  Supplementation of omega-3 fatty acids in patients with ankylosing spondylitis.  Scandinavian journal of rheumatology. 2006;39:359-362   Деменция   Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T et al.  Omega-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial.  Archives of neurology 2006;63:1402-1408   Freund-Levi Y, Basun H, Cederholm T et al.  Omega-3 supplementation in mild to moderate Alzheimer’s disease: effects on neuropsychiatric symptoms.  Internat J Geriatric Psych 2008;23(2):161-169   Faxen-Irving G, Freund-Levi Y, Eriksdotter Jonhagen M, et al.  N-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer’s disease.  Journal Am Geriatric Soc 2009;57:11-17   Vedin I, Cederholm T, Freund Levi Y, et al.  Effects of docosahexaenoic acid–rich n3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study.  Am J Clin Nutr 2008;87:1616 –22   Lai KL, Shahar S, Chin AV, et al.  Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. 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Safety aspects of dietary n-3 fatty acids.  Springer Verlag 1995;18:195-206 Други   Bioavailability:  Dyerberg J, Madsen P, Møller JM et al. N-3 fatty acids in prevention and treatment in vascular disease. Springer Verlag 1995;20:201-217   Bioavailability:  Nordøy A, Barstad L, Connor WE et al. Absorption of the n-3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans. Am J Clin Nutr 1991;53:1185-1190   Bioavailability:  Dyerberg J, Madsen P, Møller JM. Bioavailability of n-3 fatty acid formulations. Springer Verlag 1995;20:217-226   Transplantation:  Hansen JM, Løkkegaard H, Hoy CE et al. No effect of dietary fish oil on renal hemodynamics, tubular function, and renal function reserve in long-term renal transplant recipients. J Am Soc Nephrol 1995;5:1434-1440   Transplantation:  Hansen JM, Hoy CE, Strandgaard. Fish oil and cyclosporin A induced renal hypoperfusion in kidney-transplanted patients. Nephrology Dialysis Transplantation 1995;10:1745-1750   Physical performance:  Raastad T, Høstmark AT, Strømme SB. Omega-3 fatty acid supplementation does not improve maximal aerobic power, anaerobic threshold and running performance in well-trained soccer players. Scand J Med Sci Sports 1997;7:25-31   Digestion:  Riber C, Højgaard L, Madsen JL et al. Gallbladder emptying and cholecystokinin response to fish oil and trioleate ingestion. Digestion 1996;57(3):161-164   Weight reduction:  Kunnesova M, Srbova L, Hlavaty P et al. Praha omega-3 weight reduction study. ECO 2008; abstract   Infection:  Abu-Zeid YA, Hansen HS, Jakobsen PH et al. No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on plasmodium falciparum bloodstage parasites in vitro. Eur J Clin Nutr 1993;47:431-436   Depression:  Voggt A, Berger M, Obermeier M, Löw A, Seemueller F, Riedel M, Moeller HJ, Zimmermann R, Kirchberg F, Von Schacky C, Severus E. Heart rate variability and Omega-3 Index in euthymic patients with bipolar disorders. Eur Psychiatry  2015:30(2):228-232   Analysis:  Sjövall,P., Rossmeisl,M., Hanrieder,J., Kuda,O., Kopecky,J., and Bryhn,M. Dietary uptake of omega-3 fatty acids in mouse tissue studied by time-of-flight secondary ion mass spectrometry (TOF-SIMS), Analytical and bioanalytical chemistry 2015;407:5101-5111.   Depression:  Parletta N, Zarnowiecki D, Cho J, Wilson A, Bogomolova S, Villani A.  A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED). Nutritional Neuroscience 2017;1411320   Psychotic Disorders:  McGorry PD, Nelson B, Markulev C.  Effect of ω-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders; The NEURAPRO Randomized Clinical Trial. JAMA Psychiatry 2017;74(1):19-27   Psychotic Disorders:  Amminger GP, Schafer MR, Schlogelhofer M, Clier CM, McGorry PD. Longer-term outcome in the prevention of psychotic disorders by the Vienna Omega-3 study. Nature communications 2015;6:7934   Eye Health:  McDonald MB, Sheha H, Tighe S, Janik SB, Bowden FW, Chokshi AR, Singer MA, Nanda S, Qazi MA, Dierker D, Shupe AT, McMurren BJ. Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study. Clin Ophthalmol. 2018 Apr 9;12:677-681